Seismic assessment of masonry structures is a pressing concern in the scientific community. Over the last few decades, significant progress has been made in developing numerical mod-elling strategies for masonry. However, due to the unique mechanics of masonry, which ex-hibit a quasi-brittle and anisotropic behaviour, there is no trade-off between accuracy and computational efficiency when conducting numerical simulations of masonry structures. This study proposes a new approach to conduct in-plane numerical simulations of masonry struc-tures, which couple limit and pushover analyses considering the actual masonry pattern. The first step of the procedure involves a block-based limit analysis, which considers the actual masonry pattern. Macroblocks, i.e., the portions which compose the collapse mechanism, are then identified using an ad-hoc algorithm that searches for the pivot point of the obtained failure mechanisms. In the second step, a pushover analysis is conducted on the simplified structure composed of macroblocks, considered as continuum bodies, interacting via fric-tional interfaces. The proposed approach is preliminary tested on two structural-scale benchmarks made of dry-stack masonry, showing promising results.